Centrifuge-Free Bone Marrow Aspiration Device

BETTER BY DESIGN

Overcome the Disadvantages of Traditional Trocar Needles

Aspirate from multiple geographies while limiting peripheral blood dilution — from a single access site, without a centrifuge.

Traditional Trocar

Traditional open-tip trocar needle aspirating peripheral blood alongside marrow

Open Distal Tip

Aspirates freely through the open end — drawing in peripheral blood alongside marrow at a single anatomical point and diluting the cellular yield.

Cervos BMA — Marrow Cellution

Cervos BMA closed distal tip with side-port aspiration into undisturbed cancellous bone

Closed Distal Tip With Optimized Side Ports

Forces 100% of aspiration through precision side ports — blocking peripheral blood dilution and capturing higher cell counts from undisturbed cancellous bone.

BIOLOGICALLY COMPARABLE

Compared to the established gold standard for osteogenic potential — cancellous bone autograft — the aspirate obtained using the Marrow Cellution devices is functionally equivalent.^1–5

CFU-f counts and Total Nucleated Cell density track shoulder-to-shoulder with autograft across four independent studies (n = 37 pooled).

CFU-f per mL

Mesenchymal Stem & Progenitor Cell Density

Cancellous Autograftgold standard, n = 10¹

4,564

Cervos BMApooled, n = 37^2–5

5,010

Scale: 0 → 6,000 per mL

TNC ×10⁶ per mL

Total Nucleated Cells

Cancellous Autograftgold standard, n = 10¹

55.7

Cervos BMApooled, n = 37^2–5

50.5

Scale: 0 → 70 ×10⁶ per mL

Per-Study Data Breakdown

Individual sample results from each study that comprise the Cervos BMA pooled n = 37 cohort.

Study	Device / System	Sample Size n	CFU-f per mL	TNC ×10⁶ per mL
Muschler¹	Cancellous Bone Autograft (gold standard)	10	4,564	55.7
Lutz⁵	Cervos BMA — Marrow Cellution	22	4,838	47.0
Scarpone⁴	Cervos BMA — Marrow Cellution	5	5,653	43.4
Tortland³	Cervos BMA — Marrow Cellution	5	4,828	55.1
Bianco²	Cervos BMA — Marrow Cellution	5	5,309	68.5
Pooled	Cervos BMA — Marrow Cellution	37	5,010	50.5

Higher CFU-f counts per mL within bone marrow aspirate concentrate have been directly linked to superior clinical outcomes, with research establishing that specific progenitor cell thresholds must be met to achieve meaningful tissue regeneration.^6–8

References — ¹ Data on File: Muschler. · ² Data on File: Bianco. · ³ Data on File: Tortland. · ⁴ Data on File: Scarpone. · ⁵ Data on File: Lutz. · ⁶ Hernigou (2002). · ⁷ Hernigou (2005). · ⁸ Pettine (2015).

WHY MARROW CELLUTION

Eliminate the Need for a Centrifuge

Minimize Procedure Time: Aspirate to Application®

A 2-minute harvest, compared to 20 minutes required when using traditional Bone Marrow Aspiration Concentration (BMAC) systems.

Capital Equipment Burden

High upfront and ongoing costs: centrifugation systems require significant capital investment, routine maintenance, and dedicated space, increasing total procedural cost beyond the disposables themselves.

Sterile Field Complications

Transferring aspirate out of the sterile field for processing introduces additional handling steps, workflow complexity, and potential contamination or re-entry challenges.

Frequently Asked Questions

What is centrifuge-free bone marrow aspiration?

Centrifuge-free bone marrow aspiration uses a precision-engineered cannula with a closed distal tip and lateral side ports to draw aspirate exclusively from undisturbed cancellous bone, blocking peripheral blood dilution at the source. The result is a clinically meaningful cell concentration without centrifugation — eliminating the capital equipment, sterile-field handoff, and 15–20 minute off-field processing time of traditional Bone Marrow Aspirate Concentrate (BMAC) workflows. Aspiration to Application® takes under two minutes.

How does Marrow Cellution compare to BMAC?

Across four pooled independent studies (n=37), aspirate obtained using the Marrow Cellution™ device produced average CFU-f counts of 5,010 per mL and total nucleated cell density of 50.5 million per mL — within the range of cancellous bone autograft (4,564 CFU-f/mL; 55.7M TNC/mL). The harvest takes approximately two minutes versus the ~20 minutes typical of BMAC centrifugation, eliminates capital equipment requirements, and keeps the entire procedure within a single sterile field.

Sources

CFU-f and TNC values (Marrow Cellution and autograft comparison, n=37 across 4 studies): Cervos Data on File — same data already cited as “Data on File” on the BMA Sales Aid.
Hernigou P, Homma Y, Flouzat-Lachaniette CH, et al. Cancellous bone autograft and bone marrow aspirate concentrate in regenerative medicine. Int Orthop. 2014;38(9):1875–1881.

How long does bone marrow aspiration take with Marrow Cellution?

A typical bone marrow aspirate harvest using the Marrow Cellution™ device takes approximately two minutes from access to delivery. The device aspirates directly from cancellous bone through precision side ports with no centrifugation step required. Traditional Bone Marrow Aspirate Concentrate workflows generally require 15–20 minutes of off-field processing — the time savings are meaningful in OR settings and procedure scheduling.

What applications has bone marrow aspirate been studied in?

Bone marrow aspirate has been investigated across a range of orthopedic and regenerative medicine applications. The Cervos Marrow Cellution™ device specifically has been used in peer-reviewed studies addressing knee osteoarthritis, hip osteoarthritis and labral tears, shoulder osteoarthritis, subchondral bone marrow lesions, spine fusion supplementation, and critical limb ischemia, among other applications. The Cervos resources page lists 17+ published studies. Decisions about clinical use are made by the treating physician based on the patient, the procedure, and the published evidence relevant to the specific application.