Browse the Cervos resource library to explore the latest advancements in autologous orthobiologic technology, access procedural videos, and review published literature.
Thought Leadership
Published Literature
| Citation | Product(s) | Indication Focus | Link |
|---|---|---|---|
| Oyadomari, S., Ranawat, A., & Wang, D. (2025). Centrifuge-free bone marrow aspirate harvest for orthopaedic applications. Arthroscopy Techniques, 103721. | Marrow Cellution | Orthopedics | View Study |
| Caradonna, E., et al. (2023). Different methods of bone marrow harvesting influence cell characteristics and purity, affecting clinical outcomes. JVS-Vascular Science, 4, 100130. | Marrow Cellution | Critical Limb Ischemia | View Study |
| Pearl, A., Saleh, K., Korsog, D., & Mundt, J. (2023). Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: A retrospective review of a veteran cohort. Regenerative Medicine, 18(11), 833–838. | Marrow Cellution | Knee Cartilage | View Study |
| Pintore, A., Notarfrancesco, D., Zara, A., Oliviero, A., Migliorini, F., Oliva, F., & Maffulli, N. (2023). Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: A prospective comparative clinical trial. Journal of Orthopaedic Surgery and Research, 18, Article 350. | Marrow Cellution + Adipose | Knee OA | View Study |
| Kuebler, D., Schnee, A., Moore, L., Kouri, J., McLaughlin, A., Hanson, R., Kuebler, P., Dallo, I., & Gobbi, A. (2022). Short-term efficacy of using a novel low-volume bone marrow aspiration technique to treat knee osteoarthritis: A retrospective cohort study. Stem Cells International, 2022, 5394441. | Marrow Cellution | Knee OA | View Study |
| Day, M. A., Hancock, K. J., Selley, R. S., Olsen, R., Ranawat, A. S., Nwachukwu, B. U., Kelly, B. T., & Nawabi, D. H. (2022). Hip arthroscopy with bone marrow aspirate injection for patients with symptomatic labral tears and early degenerative changes shows similar improvement compared with patients undergoing hip arthroscopy with symptomatic labral tears without arthritis. Arthroscopy. | Marrow Cellution | Hip Labral Tears | View Study |
| Tsitsilianos, N., Shirazi, Z., Lu, J., & Singh, J. R. (2022). Bone marrow aspirate injection for osteoarthritis of the hip: A pilot study. Interventional Pain Medicine, 1(4), 100163. | Marrow Cellution | Hip OA | View Study |
| Dwyer, T., Hoit, G., Lee, A., Watkins, E., Henry, P., Leroux, T., Veillette, C., Theodoropoulos, J., Ogilvie-Harris, D., & Chahal, J. (2021). Injection of bone marrow aspirate for glenohumeral joint osteoarthritis: A pilot randomized control trial. Arthroscopy, Sports Medicine, and Rehabilitation, 3(5), e1431–e1440. | Marrow Cellution | Shoulder OA | View Study |
| Viganò, M., Ragni, E., Di Matteo, B., Gambaro, F. M., Perucca Orfei, C., Spinelli, G., Colombini, A., di Girolamo, L., & Kon, E. (2021). A single-step, centrifuge-free method to harvest bone marrow highly concentrated in mesenchymal stem cells: Results of a pilot trial. International Orthopaedics, 46(1), 391–400. | Marrow Cellution | Cell Harvesting | View Study |
| Sobti, A. S., Baryeh, K. W., Woolf, R., & Chana, R. (2020). Autologous matrix-induced chondrogenesis and bone marrow aspirate concentrate compared with microfracture for arthroscopic treatment of femoroacetabular impingement and chondral lesions of the hip: Bridging the osteoarthritis gap and facilitating enhanced recovery. Journal of Hip Preservation Surgery, 7(3), 503–510. | Marrow Cellution | Hip | View Study |
| Varady, N. H., Cate, G., Barghi, A., Yakin, D., Ylanan, R. C., & Arnold, C. A. (2020). Positive early clinical outcomes of bone marrow aspirate concentrate for osteoarthritis using a novel fenestrated trocar. Journal of Cartilage and Joint Preservation, 27(5), 1627–1634. | Marrow Cellution | Knee OA | View Study |
| Prodromos, C., & Finkle, S. (2020). Autologous biologic treatment with fat, bone marrow aspirate and platelet rich plasma is an effective alternative to total knee arthroplasty for patients with moderate knee arthrosis. Medicines, 7(6), 37. | Marrow Cellution + PRP + Adipose | Knee OA | View Study |
| Bieri, M., Said, E., Antonini, G., Dickerson, D., Tuma, J., Bartlett, C. E., Patel, A. N., & Gershman, A. (2020). Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction. Journal of Translational Medicine, 18, Article 24. | Marrow Cellution | Erectile Dysfunction | View Study |
| Scarpone, M., Kuebler, D., Chambers, A., et al. (2019). Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine, 17, 10. | Marrow Cellution | Cell Harvesting | View Study |
| Wells, K., Klein, M., Hurwitz, N., Santiago, K., Cheng, J., Abutalib, Z., Beatty, N., & Lutz, G. (2020). Cellular and clinical analyses of autologous bone marrow aspirate injectate for knee osteoarthritis: A pilot study. Pain Medicine, 21(6), 12429. | Marrow Cellution | Knee OA | View Study |
| Colberg, R. E., Jurado Vélez, J. A., Walsh, K. P., & Fleisig, G. (2020). Short-term outcomes after pure bone marrow aspirate injection for severe knee osteoarthritis: A case series. Regenerative Medicine, 15(18), 1851–1859. | Marrow Cellution | Knee OA | View Study |
| Lutz, G. E. (2023). Intradiscal leukocyte-rich platelet-rich plasma for degenerative disc disease. Physical Medicine and Rehabilitation Clinics of North America, 34(1), 117–133. | KeyPRP | Degenerative Disc Disease | View Study |
| Herman, K., et al. (2023). Osteo-core plasty: A minimally invasive approach for subchondral pathologies. Journal of Cartilage & Joint Preservation, 3(1), 100101. | Marrow Cellution + PercuGraft Bone Dowel | Subchondral Pathologies | View Study |
| Dallo, I., D’Ambrosi, R., Szwedowski, D., Mobasheri, A., & Gobbi, A. (2022). Minimally invasive cell-based therapy for symptomatic bone marrow lesions of the knee: A prospective clinical study at 1 year. Stem Cells and Development, 31(15–16). | Marrow Cellution + PercuGraft Bone Dowel | Subchondral Pathologies | View Study |
| Gobbi, A., Morales, M., & Valsecchi, G. (2022). Biologic knee arthroplasty in 360 degrees for early osteoarthritis treatment. Medical Research Archives, 10(3). | Marrow Cellution + PercuGraft Bone Dowel | Knee OA | View Study |
| Gobbi, A., Dallo, I., Frank, R. M., Bradsell, H., Saenz, I., & Murrel, W. (2021). A review of bone marrow lesions in the arthritic knee and description of a technique for treatment. Journal of Cartilage and Joint Preservation, 1(3), 100021. | Marrow Cellution + PercuGraft Bone Dowel | Knee OA | View Study |
| Henderson, R. G., & Colberg, R. E. (2018). Pure bone marrow aspirate injection for chronic greater trochanteric pain syndrome: A case report. Pain Management, 8(4), 271–275. | Marrow Cellution | Greater Trochanteric Pain Syndrome | View Study |
| Easley, J. T., Sikes, K. J., Bisazza, K., Meyers, M., Stewart, H. L., & Reves, B. (2023). Preclinical evaluation of Marrow Cellution needle compared to traditional aspiration and BioCUE centrifugation system [Conference poster]. Orthopaedic Research Society Annual Meeting, Colorado State University, Department of Clinical Sciences. | Marrow Cellution vs. BioCUE | Cell Harvesting | View Study |
The Science Behind the Technology
Peer-reviewed evidence behind the core orthobiologic technologies — platelet dose and composition for PRP, and bone-marrow progenitor (CFU-f) concentration. This literature informs the science Cervos systems are designed around; these studies were not necessarily conducted with Cervos devices.
| Citation | Technology | Focus | Level of Evidence | Link |
|---|---|---|---|---|
| Bansal, H., Leon, J., Pont, J. L., et al. (2021). Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: correct dose critical for long-term clinical efficacy. Scientific Reports, 11, 3971. | PRP | Platelet dose threshold · Knee OA | Level I (RCT) | View Study |
| Berrigan, W. A., Bailowitz, Z., Park, A., Reddy, A., Liu, R., & Lansdown, D. (2024). A greater platelet dose may yield better clinical outcomes for platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review. Arthroscopy, 41(3), 809–817. | PRP | Platelet dose · Knee OA | Level II (systematic review) | View Study |
| Bensa, A., Previtali, D., Sangiorgio, A., Boffa, A., Salerno, M., & Filardo, G. (2025). PRP injections for the treatment of knee osteoarthritis: the improvement is clinically significant and influenced by platelet concentration — a meta-analysis of randomized controlled trials. American Journal of Sports Medicine, 53(3), 745–754. | PRP | Platelet concentration · Knee OA | Level I (meta-analysis) | View Study |
| Oeding, J. F., Varady, N. H., Messer, C. J., Dines, J. S., Williams, R. J., & Rodeo, S. A. (2025). Platelet concentration explains variability in outcomes of platelet-rich plasma for lateral epicondylitis: a systematic review and meta-analysis with meta-regression. American Journal of Sports Medicine, 53(10), 2489–2496. | PRP | Platelet concentration · Lateral epicondylitis | Level II (meta-analysis) | View Study |
| Riboh, J. C., Saltzman, B. M., Yanke, A. B., Fortier, L., & Cole, B. J. (2016). Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis. American Journal of Sports Medicine, 44(3), 792–800. | PRP | Leukocyte composition (LR vs LP) · Knee OA | Level I (meta-analysis) | View Study |
| Patel, S., Dhillon, M. S., Aggarwal, S., Marwaha, N., & Jain, A. (2013). Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. American Journal of Sports Medicine, 41(2), 356–364. | PRP | Knee OA | Level I (RCT) | View Study |
| Filardo, G., Di Matteo, B., Di Martino, A., et al. (2015). Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. American Journal of Sports Medicine, 43(7), 1575–1582. (5-year follow-up: Di Martino, A., et al., 2019, 47(2), 347–354.) | PRP | Knee OA (vs viscosupplementation) | Level I (RCT) | View Study |
| Görmeli, G., Görmeli, C. A., Ataoglu, B., Çolak, C., Aslantürk, O., & Ertem, K. (2017). Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surgery, Sports Traumatology, Arthroscopy, 25(3), 958–965. | PRP | Knee OA (injection number) | Level I (RCT) | View Study |
| Dallari, D., Stagni, C., Rani, N., et al. (2016). Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a randomized controlled study. American Journal of Sports Medicine, 44(3), 664–671. | PRP | Hip OA | Level I (RCT) | View Study |
| Mishra, A. K., Skrepnik, N. V., Edwards, S. G., et al. (2014). Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. American Journal of Sports Medicine, 42(2), 463–471. | PRP | Lateral epicondylitis | Level II (RCT) | View Study |
| Peerbooms, J. C., Sluimer, J., Bruijn, D. J., & Gosens, T. (2010). Positive effect of an autologous platelet concentrate in lateral epicondylitis: PRP versus corticosteroid injection with a 1-year follow-up. American Journal of Sports Medicine, 38(2), 255–262. (2-year follow-up: Gosens, T., et al., 2011, 39(6), 1200–1208.) | PRP | Lateral epicondylitis (vs corticosteroid) | Level I (RCT) | View Study |
| Krogh, T. P., Fredberg, U., Stengaard-Pedersen, K., Christensen, R., Jensen, P., & Ellingsen, T. (2013). Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. American Journal of Sports Medicine, 41(3), 625–635. | PRP | Lateral epicondylitis | Level I (RCT) | View Study |
| Dragoo, J. L., Wasterlain, A. S., Braun, H. J., & Nead, K. T. (2014). Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. American Journal of Sports Medicine, 42(3), 610–618. | PRP | Patellar tendinopathy | Level I (RCT) | View Study |
| Pandey, V., Bandi, A., Madi, S., et al. (2016). Does application of moderately concentrated platelet-rich plasma improve clinical and structural outcome after arthroscopic repair of medium-sized to large rotator cuff tear? A randomized controlled trial. Journal of Shoulder and Elbow Surgery, 25(8), 1312–1322. | PRP | Rotator cuff repair | Level I (RCT) | View Study |
| Chen, X., Jones, I. A., Togashi, R., Park, C., & Vangsness, C. T. Jr. (2020). Use of platelet-rich plasma for the improvement of pain and function in rotator cuff tears: a systematic review and meta-analysis with bias assessment. American Journal of Sports Medicine, 48(8), 2028–2041. | PRP | Rotator cuff | Level I (meta-analysis) | View Study |
| Randelli, P., Arrigoni, P., Ragone, V., Aliprandi, A., & Cabitza, P. (2011). Platelet-rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. Journal of Shoulder and Elbow Surgery, 20(4), 518–528. | PRP | Rotator cuff repair | Level I (RCT) | View Study |
| Tuakli-Wosornu, Y. A., Terry, A., Boachie-Adjei, K., et al. (2016). Lumbar intradiskal platelet-rich plasma (PRP) injections: a prospective, double-blind, randomized controlled study. PM&R, 8(1), 1–10. | PRP | Discogenic low back pain (intradiscal) | Level I (RCT) | View Study |
| Akeda, K., Ohishi, K., Takegami, N., et al. (2022). Platelet-rich plasma releasate versus corticosteroid for the treatment of discogenic low back pain: a double-blind randomized controlled trial. Journal of Clinical Medicine, 11(2), 304. | PRP | Discogenic low back pain (intradiscal) | Level I (RCT) | View Study |
| Hernigou, P., et al. (2005). Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells. Journal of Bone and Joint Surgery (American), 87(7), 1430–1437. | BMA | Progenitor (CFU-f) concentration · Bone healing | Clinical study (n=60) | View Study |
| Hernigou, P., Homma, Y., Flouzat-Lachaniette, C. H., et al. (2013). Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells. International Orthopaedics, 37(11), 2279–2287. | BMA | Aspiration technique · CFU-f / MSC yield | Controlled comparative study | View Study |
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